TY - JOUR
T1 - Long-term survival, health, social functioning, and education in patients with an enterovirus central nervous system infection, Denmark, 1997-2016
AU - Omland, Lars H
AU - Holm-Hansen, Charlotte
AU - Lebech, Anne-Mette
AU - Dessau, Ram B
AU - Bodilsen, Jacob
AU - Andersen, Nanna S
AU - Roed, Casper
AU - Christiansen, Claus B
AU - Ellermann-Eriksen, Svend
AU - Midgley, Sofie
AU - Nielsen, Lene
AU - Benfield, Thomas
AU - Hansen, Ann-Brit E
AU - Andersen, Christian Ø
AU - Rothman, Kenneth J
AU - Sørensen, Henrik T
AU - Fischer, Thea K
AU - Obel, Niels
N1 - .
PY - 2020/8
Y1 - 2020/8
N2 - BACKGROUND: The long-term clinical course of patients with an enterovirus central nervous system infection (ECI) is poorly understood.METHODS: We performed a nationwide population-based cohort study of all Danish patients with ECI diagnosed 1997-2016 (n = 1745) and a comparison cohort from the general population individually matched on date of birth and sex (n = 17 450). Outcomes were categorized into mortality and risk of cancer and likely measures of neurological sequelae: neuropsychiatric morbidities, educational landmarks, use of hospital services, employment, receipt of disability pension, income, number of sick leave days, and nursing home residency.RESULTS: Mortality in the first year was higher among patients with ECI (mortality rate ratio [MRR] = 10.0; 95% confidence interval [CI], 4.17-24.1), but thereafter mortality was not higher (MMR = 0.94; 95% CI, 0.47-1.86). Long-term outcomes for patients with ECI were not inferior to those of the comparison cohort for risk of cancer, epilepsy, mental and behavioral disorders, dementia, depression, school start, school marks, high school education, use of hospital services, employment, receipt of disability pension, income, days of sick leave, or nursing home residency.CONCLUSIONS: Diagnosis of an ECI had no substantial impact on long-term survival, health, or social/educational functioning.
AB - BACKGROUND: The long-term clinical course of patients with an enterovirus central nervous system infection (ECI) is poorly understood.METHODS: We performed a nationwide population-based cohort study of all Danish patients with ECI diagnosed 1997-2016 (n = 1745) and a comparison cohort from the general population individually matched on date of birth and sex (n = 17 450). Outcomes were categorized into mortality and risk of cancer and likely measures of neurological sequelae: neuropsychiatric morbidities, educational landmarks, use of hospital services, employment, receipt of disability pension, income, number of sick leave days, and nursing home residency.RESULTS: Mortality in the first year was higher among patients with ECI (mortality rate ratio [MRR] = 10.0; 95% confidence interval [CI], 4.17-24.1), but thereafter mortality was not higher (MMR = 0.94; 95% CI, 0.47-1.86). Long-term outcomes for patients with ECI were not inferior to those of the comparison cohort for risk of cancer, epilepsy, mental and behavioral disorders, dementia, depression, school start, school marks, high school education, use of hospital services, employment, receipt of disability pension, income, days of sick leave, or nursing home residency.CONCLUSIONS: Diagnosis of an ECI had no substantial impact on long-term survival, health, or social/educational functioning.
KW - enterovirus meningitis
KW - meningitis
KW - viral meningitis
UR - http://www.scopus.com/inward/record.url?scp=85088531687&partnerID=8YFLogxK
U2 - 10.1093/infdis/jiaa151
DO - 10.1093/infdis/jiaa151
M3 - Journal article
C2 - 32236420
SN - 0022-1899
VL - 222
SP - 619
EP - 627
JO - The Journal of Infectious Diseases
JF - The Journal of Infectious Diseases
IS - 4
ER -