TY - JOUR
T1 - Plasma linoleic acid levels and cardiovascular risk factors
T2 - results from the Norwegian ACE 1950 Study
AU - Chandra, Anupam
AU - Røsjø, Helge
AU - Svensson, My
AU - Vigen, Thea
AU - Ihle-Hansen, Håkon
AU - Orstad, Eivind Bjørkan
AU - Rønning, Ole Morten
AU - Lyngbakken, Magnus Nakrem
AU - Nygård, Ståle
AU - Berge, Trygve
AU - Schmidt, Erik Berg
AU - Omland, Torbjørn
AU - Tveit, Arnljot
AU - Eide, Ivar Anders
PY - 2020/12
Y1 - 2020/12
N2 - BACKGROUND: A high intake of linoleic acid (LA), the major dietary polyunsaturated fatty acid (PUFA), has previously been associated with reduced cardiovascular (CV) morbidity and mortality in observational studies. However, recent secondary analyses from clinical trials of LA-rich diet suggest harmful effects of LA on CV health.METHODS: A total of 3706 participants, all born in 1950, were included in this cross-sectional study. We investigated associations between plasma phospholipid levels of LA and CV risk factors in a Norwegian general population, characterized by a relative low LA and high marine n-3 PUFA intake. The main statistical approach was multivariable linear regression.RESULTS: Plasma phospholipid LA levels ranged from 11.4 to 32.0 wt%, with a median level of 20.8 wt% (interquartile range 16.8-24.8 wt%). High plasma LA levels were associated with lower serum low-density lipoprotein cholesterol levels (standardized regression coefficient [Std. β-coeff.] -0.04, p = 0.02), serum triglycerides (Std. β-coeff. -0.10, p < 0.001), fasting plasma glucose (Std. β-coeff. -0.10, p < 0.001), body mass index (Std. β-coeff. -0.13, p < 0.001), systolic and diastolic blood pressure (Std. β-coeff. -0.04, p = 0.03 and Std. β-coeff. -0.02, p = 0.02, respectively) and estimated glomerular filtration rate (Std. β-coeff. -0.09, p < 0.001). We found no association between plasma LA levels and high-density lipoprotein cholesterol levels, glycated hemoglobin, carotid intima-media thickness, or C-reactive protein.CONCLUSION: High plasma LA levels were favorably associated with several CV risk factors in this study of a Norwegian general population.
AB - BACKGROUND: A high intake of linoleic acid (LA), the major dietary polyunsaturated fatty acid (PUFA), has previously been associated with reduced cardiovascular (CV) morbidity and mortality in observational studies. However, recent secondary analyses from clinical trials of LA-rich diet suggest harmful effects of LA on CV health.METHODS: A total of 3706 participants, all born in 1950, were included in this cross-sectional study. We investigated associations between plasma phospholipid levels of LA and CV risk factors in a Norwegian general population, characterized by a relative low LA and high marine n-3 PUFA intake. The main statistical approach was multivariable linear regression.RESULTS: Plasma phospholipid LA levels ranged from 11.4 to 32.0 wt%, with a median level of 20.8 wt% (interquartile range 16.8-24.8 wt%). High plasma LA levels were associated with lower serum low-density lipoprotein cholesterol levels (standardized regression coefficient [Std. β-coeff.] -0.04, p = 0.02), serum triglycerides (Std. β-coeff. -0.10, p < 0.001), fasting plasma glucose (Std. β-coeff. -0.10, p < 0.001), body mass index (Std. β-coeff. -0.13, p < 0.001), systolic and diastolic blood pressure (Std. β-coeff. -0.04, p = 0.03 and Std. β-coeff. -0.02, p = 0.02, respectively) and estimated glomerular filtration rate (Std. β-coeff. -0.09, p < 0.001). We found no association between plasma LA levels and high-density lipoprotein cholesterol levels, glycated hemoglobin, carotid intima-media thickness, or C-reactive protein.CONCLUSION: High plasma LA levels were favorably associated with several CV risk factors in this study of a Norwegian general population.
UR - http://www.scopus.com/inward/record.url?scp=85084136591&partnerID=8YFLogxK
U2 - 10.1038/s41430-020-0641-4
DO - 10.1038/s41430-020-0641-4
M3 - Journal article
C2 - 32341488
SN - 0954-3007
VL - 74
SP - 1707
EP - 1717
JO - European Journal of Clinical Nutrition
JF - European Journal of Clinical Nutrition
IS - 12
ER -