Risk Factors and Prognosis of Epilepsy Following Brain Abscess: A Nationwide Population-Based Cohort Study

Jacob Bodilsen*, Lærke Storgaard Duerlund, Theis Mariager, Christian Thomas Brandt, Lothar Wiese, Pelle Trier Petersen, Lykke Larsen, Birgitte Rønde Hansen, Lars Haukali Omland, Malte Mose Tetens, Rasmus Langelund Jørgensen, Steffen Leth, Henrik Nielsen


Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

3 Citationer (Scopus)


Background and objectives: Epilepsy in patients with brain abscess is frequent but risk factors and prognosis remain undetermined. This study examined risk factors for epilepsy among survivors of brain abscess and associated prognosis.

Methods: Nationwide, population-based healthcare registries were used to compute cumulative incidences and cause-specific adjusted hazard rate ratios (adj. HRRs) with 95% confidence intervals (CIs) for epilepsy among 30-day survivors of brain abscess from 1982 through 2016. Data was enriched with clinical details by medical record review of patients hospitalized from 2007 through 2016. Adjusted mortality rate ratios (adj. MRRs) were examined using epilepsy as a time-dependent variable.

Results: The study included 1,179 30-day survivors of brain abscess among whom 323 (27%) developed new-onset epilepsy after a median of 0.76 years (interquartile range [IQR] 0.24-2.41). At admission for brain abscess, the median age was 46 years (IQR 32-59) in patients with epilepsy compared with 52 years (IQR 33-64) in those without epilepsy. The proportion of females was similar in patients with and without epilepsy (37%). Adj. HRRs for epilepsy were 2.44 (95% CI 1.89-3.15) for aspiration or excision of brain abscess, 2.37 (1.56-3.60) for alcohol abuse, 1.75 (1.27-2.40) for previous neurosurgery or head trauma, 1.62 (1.17-2.25) for stroke, and 1.55 (1.04-2.32) for age group 20-39 years. Cumulative incidences were increased in patients with alcohol abuse (52% vs 31%), aspiration or excision of brain abscess (41% vs. 20%), previous neurosurgery or head trauma (41% vs. 31%), and stroke (46% vs. 31%). Analysis using clinical details from medical record review of patients from 2007 through 2016 demonstrated adj. HRRs of 3.70 (2.24-6.13) for seizures at admission for brain abscess and 1.80 (1.04-3.11) for frontal lobe abscess. In contrast, adj. HRR was 0.42 (0.21-0.86) for occipital lobe abscess.

Using the entire registry-based cohort, patients with epilepsy had an adj. MRR of 1.26 (1.01-1.57).

Discussion: Important risk factors for epilepsy were seizures during admission for brain abscess, neurosurgery, alcoholism, frontal lobe abscess, and stroke. Epilepsy was associated with increased mortality. Anti-epileptic treatment may be guided by individual risk profiles and specialized follow-up is highlighted by increased mortality in survivors with epilepsy.
Udgave nummer15
Sider (fra-til)e1611-e1620
Antal sider10
StatusUdgivet - 11 apr. 2023

Bibliografisk note

© 2023 American Academy of Neurology.


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