The PanGut-study: Evoked potentials following rectal balloon distention, a way of evaluating diabetic autonomic neuropathy in the gut?

Sondre Meling; Erling Tjora; Heike Eichele; Rasmus Bach Nedergaard; Niels Ejskjaer; Christina Brock; Eirik Søfteland

doi:10.1016/j.jdiacomp.2023.108452

The PanGut-study: Evoked potentials following rectal balloon distention, a way of evaluating diabetic autonomic neuropathy in the gut?

Sondre Meling^*, Erling Tjora, Heike Eichele, Rasmus Bach Nedergaard, Niels Ejskjaer, Christina Brock, Eirik Søfteland

^*Kontaktforfatter

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

2 Citationer (Scopus)

Abstract

Aim: There is a lack of methods for investigating the autonomic nerves of the gastrointestinal tract. Our aim was to explore a novel test measuring visceral sensory evoked potentials (EPs) in response to rapid balloon distention in the rectum and compare it to established tests for diabetic neuropathy.

Method: Participants with longstanding type 2 diabetes, newly onset, untreated diabetes
Results: The pressure at earliest sensation was higher in people with diabetes, 0.038 (0.012) bar vs. controls 0.030 (0.009) bar, p = 0.002, and in people with signs of peripheral neuropathy, 0.045 (0.014) bar, p < 0.01. Clinical correlations between EP amplitude and latency, and other tests were found.

Conclusions: Rectal hyposensitivity was associated with both longstanding and early diabetes, indicating enteric sensory dysfunction already in early stages of diabetes. Correlation analyses may indicate that central afferent processing is affected in parallel with peripheral neuronal function.

Originalsprog	Engelsk
Artikelnummer	108452
Tidsskrift	Journal of Diabetes and its Complications
Vol/bind	37
Udgave nummer	5
Antal sider	9
ISSN	1056-8727
DOI	https://doi.org/10.1016/j.jdiacomp.2023.108452
Status	Udgivet - maj 2023

Bibliografisk note

Korrektion publiceret her:
Corrigendum to “The PanGut-study: Evoked potentials following rectal balloon distention, a way of evaluating diabetic autonomic neuropathy in the gut?”
Journal of Diabetes and its Complications, Volume 37, Issue 10, October 2023, Pages 108612. https://doi.org/10.1016/j.jdiacomp.2023.108612

Copyright © 2023 Elsevier Inc. All rights reserved.

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10.1016/j.jdiacomp.2023.108452

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Citationsformater

@article{675046a2975f435eadfc2587cf45108d,

title = "The PanGut-study: Evoked potentials following rectal balloon distention, a way of evaluating diabetic autonomic neuropathy in the gut?",

abstract = "Aim: There is a lack of methods for investigating the autonomic nerves of the gastrointestinal tract. Our aim was to explore a novel test measuring visceral sensory evoked potentials (EPs) in response to rapid balloon distention in the rectum and compare it to established tests for diabetic neuropathy. Method: Participants with longstanding type 2 diabetes, newly onset, untreated diabetes <1 year, and matched controls, were included. Tests included cardiovascular reflex tests, orthostatic blood pressure, electrical skin conductance assessment, sural nerve testing and monofilament test. The rectal balloon distention pressure at earliest sensation and threshold of unpleasantness were identified and used to elicit mechanical EPs. Results: The pressure at earliest sensation was higher in people with diabetes, 0.038 (0.012) bar vs. controls 0.030 (0.009) bar, p = 0.002, and in people with signs of peripheral neuropathy, 0.045 (0.014) bar, p < 0.01. Clinical correlations between EP amplitude and latency, and other tests were found. Conclusions: Rectal hyposensitivity was associated with both longstanding and early diabetes, indicating enteric sensory dysfunction already in early stages of diabetes. Correlation analyses may indicate that central afferent processing is affected in parallel with peripheral neuronal function.",

keywords = "Diabetes Mellitus, Type 2/complications, Diabetic Neuropathies/diagnosis, Evoked Potentials/physiology, Gastrointestinal Tract, Humans, Rectum/innervation, Type 2 diabetes, Diabetic autonomic neuropathy, Rectal hyposensitivity, Evoked potentials, Rectal balloon distention",

author = "Sondre Meling and Erling Tjora and Heike Eichele and Nedergaard, {Rasmus Bach} and Niels Ejskjaer and Christina Brock and Eirik S{\o}fteland",

note = "Corrigendum has been published here: Corrigendum to “The PanGut-study: Evoked potentials following rectal balloon distention, a way of evaluating diabetic autonomic neuropathy in the gut?” Journal of Diabetes and its Complications, Volume 37, Issue 10, October 2023, Pages 108612. https://doi.org/10.1016/j.jdiacomp.2023.108612 Copyright {\textcopyright} 2023 Elsevier Inc. All rights reserved.",

year = "2023",

month = may,

doi = "10.1016/j.jdiacomp.2023.108452",

language = "English",

volume = "37",

journal = "Journal of Diabetes and its Complications",

issn = "1056-8727",

publisher = "Elsevier",

number = "5",

}

TY - JOUR

T1 - The PanGut-study

T2 - Evoked potentials following rectal balloon distention, a way of evaluating diabetic autonomic neuropathy in the gut?

AU - Meling, Sondre

AU - Tjora, Erling

AU - Eichele, Heike

AU - Nedergaard, Rasmus Bach

AU - Ejskjaer, Niels

AU - Brock, Christina

AU - Søfteland, Eirik

N1 - Corrigendum has been published here: Corrigendum to “The PanGut-study: Evoked potentials following rectal balloon distention, a way of evaluating diabetic autonomic neuropathy in the gut?” Journal of Diabetes and its Complications, Volume 37, Issue 10, October 2023, Pages 108612. https://doi.org/10.1016/j.jdiacomp.2023.108612 Copyright © 2023 Elsevier Inc. All rights reserved.

PY - 2023/5

Y1 - 2023/5

N2 - Aim: There is a lack of methods for investigating the autonomic nerves of the gastrointestinal tract. Our aim was to explore a novel test measuring visceral sensory evoked potentials (EPs) in response to rapid balloon distention in the rectum and compare it to established tests for diabetic neuropathy. Method: Participants with longstanding type 2 diabetes, newly onset, untreated diabetes <1 year, and matched controls, were included. Tests included cardiovascular reflex tests, orthostatic blood pressure, electrical skin conductance assessment, sural nerve testing and monofilament test. The rectal balloon distention pressure at earliest sensation and threshold of unpleasantness were identified and used to elicit mechanical EPs. Results: The pressure at earliest sensation was higher in people with diabetes, 0.038 (0.012) bar vs. controls 0.030 (0.009) bar, p = 0.002, and in people with signs of peripheral neuropathy, 0.045 (0.014) bar, p < 0.01. Clinical correlations between EP amplitude and latency, and other tests were found. Conclusions: Rectal hyposensitivity was associated with both longstanding and early diabetes, indicating enteric sensory dysfunction already in early stages of diabetes. Correlation analyses may indicate that central afferent processing is affected in parallel with peripheral neuronal function.

AB - Aim: There is a lack of methods for investigating the autonomic nerves of the gastrointestinal tract. Our aim was to explore a novel test measuring visceral sensory evoked potentials (EPs) in response to rapid balloon distention in the rectum and compare it to established tests for diabetic neuropathy. Method: Participants with longstanding type 2 diabetes, newly onset, untreated diabetes <1 year, and matched controls, were included. Tests included cardiovascular reflex tests, orthostatic blood pressure, electrical skin conductance assessment, sural nerve testing and monofilament test. The rectal balloon distention pressure at earliest sensation and threshold of unpleasantness were identified and used to elicit mechanical EPs. Results: The pressure at earliest sensation was higher in people with diabetes, 0.038 (0.012) bar vs. controls 0.030 (0.009) bar, p = 0.002, and in people with signs of peripheral neuropathy, 0.045 (0.014) bar, p < 0.01. Clinical correlations between EP amplitude and latency, and other tests were found. Conclusions: Rectal hyposensitivity was associated with both longstanding and early diabetes, indicating enteric sensory dysfunction already in early stages of diabetes. Correlation analyses may indicate that central afferent processing is affected in parallel with peripheral neuronal function.

KW - Diabetes Mellitus, Type 2/complications

KW - Diabetic Neuropathies/diagnosis

KW - Evoked Potentials/physiology

KW - Gastrointestinal Tract

KW - Humans

KW - Rectum/innervation

KW - Type 2 diabetes

KW - Diabetic autonomic neuropathy

KW - Rectal hyposensitivity

KW - Evoked potentials

KW - Rectal balloon distention

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U2 - 10.1016/j.jdiacomp.2023.108452

DO - 10.1016/j.jdiacomp.2023.108452

M3 - Journal article

C2 - 36965366

SN - 1056-8727

VL - 37

JO - Journal of Diabetes and its Complications

JF - Journal of Diabetes and its Complications

IS - 5

M1 - 108452

ER -

The PanGut-study: Evoked potentials following rectal balloon distention, a way of evaluating diabetic autonomic neuropathy in the gut?

Abstract

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