A genome‑wide association study of social trust in 33,882 Danish blood donors

Celia  Burgos Sequeros; Thomas  Folkmann Hansen; David  Westergaard; Ioannis  Louloudis; Sebastian  Kalamajski; Timo  Röder; Palle Duun Rohde; Michael  Schwinn; Line  Harder Clemmensen; Maria  Didriksen; Mette Nyegaard; Henrik  Hjalgrim; Kaspar  René Nielsen; Mie  Topholm Bruun; Sisse  Rye Ostrowski; Christian  Erikstrup; Susan Mikkelsen; Erik Sørensen; DBDS Genomic Consortium; Ole  Birger Vestager Pedersen; Søren  Brunak; Karina  Banasik; Giuseppe  Nicola Giordano

doi:10.1038/s41598-024-51636-0

A genome‑wide association study of social trust in 33,882 Danish blood donors

Celia Burgos Sequeros, Thomas Folkmann Hansen, David Westergaard, Ioannis Louloudis, Sebastian Kalamajski, Timo Röder, Palle Duun Rohde, Michael Schwinn, Line Harder Clemmensen, Maria Didriksen, Mette Nyegaard, Henrik Hjalgrim, Kaspar René Nielsen, Mie Topholm Bruun, Sisse Rye Ostrowski, Christian Erikstrup, Susan Mikkelsen, Erik Sørensen, DBDS Genomic Consortium, Ole Birger Vestager PedersenSøren Brunak, Karina Banasik^*, Giuseppe Nicola Giordano

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brainrelated phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent metaanalysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.

Original language	English
Article number	1402
Journal	Scientific Reports
Volume	14
Issue number	1
Pages (from-to)	1-12
Number of pages	12
ISSN	2045-2322
DOIs	https://doi.org/10.1038/s41598-024-51636-0
Publication status	Published - 16 Jan 2024

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Burgos Sequeros, C., Folkmann Hansen, T., Westergaard, D., Louloudis, I., Kalamajski, S., Röder, T., Rohde, P. D., Schwinn, M., Harder Clemmensen, L., Didriksen, M., Nyegaard, M., Hjalgrim, H., René Nielsen, K., Topholm Bruun, M., Rye Ostrowski, S., Erikstrup, C., Mikkelsen, S., Sørensen, E., DBDS Genomic Consortium, ... Nicola Giordano, G. (2024). A genome‑wide association study of social trust in 33,882 Danish blood donors. Scientific Reports, 14(1), 1-12. Article 1402. https://doi.org/10.1038/s41598-024-51636-0

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title = "A genome‑wide association study of social trust in 33,882 Danish blood donors",

abstract = "Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brainrelated phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent metaanalysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.",

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Burgos Sequeros, C, Folkmann Hansen, T, Westergaard, D, Louloudis, I, Kalamajski, S, Röder, T, Rohde, PD, Schwinn, M, Harder Clemmensen, L, Didriksen, M, Nyegaard, M, Hjalgrim, H, René Nielsen, K, Topholm Bruun, M, Rye Ostrowski, S, Erikstrup, C, Mikkelsen, S, Sørensen, E, DBDS Genomic Consortium, Birger Vestager Pedersen, O, Brunak, S, Banasik, K & Nicola Giordano, G 2024, 'A genome‑wide association study of social trust in 33,882 Danish blood donors', Scientific Reports, vol. 14, no. 1, 1402, pp. 1-12. https://doi.org/10.1038/s41598-024-51636-0

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AU - Burgos Sequeros, Celia

AU - Folkmann Hansen, Thomas

AU - Westergaard, David

AU - Louloudis, Ioannis

AU - Kalamajski, Sebastian

AU - Röder, Timo

AU - Rohde, Palle Duun

AU - Schwinn, Michael

AU - Harder Clemmensen, Line

AU - Didriksen, Maria

AU - Nyegaard, Mette

AU - Hjalgrim, Henrik

AU - René Nielsen, Kaspar

AU - Topholm Bruun, Mie

AU - Rye Ostrowski, Sisse

AU - Erikstrup, Christian

AU - Mikkelsen, Susan

AU - Sørensen, Erik

AU - DBDS Genomic Consortium

AU - Birger Vestager Pedersen, Ole

AU - Brunak, Søren

AU - Banasik, Karina

AU - Nicola Giordano, Giuseppe

PY - 2024/1/16

Y1 - 2024/1/16

N2 - Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brainrelated phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent metaanalysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.

AB - Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brainrelated phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent metaanalysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.

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DO - 10.1038/s41598-024-51636-0

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JO - Scientific Reports

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ER -

A genome‑wide association study of social trust in 33,882 Danish blood donors

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