TY - JOUR
T1 - A genome‑wide association study of social trust in 33,882 Danish blood donors
AU - Burgos Sequeros, Celia
AU - Folkmann Hansen, Thomas
AU - Westergaard, David
AU - Louloudis, Ioannis
AU - Kalamajski, Sebastian
AU - Röder, Timo
AU - Rohde, Palle Duun
AU - Schwinn, Michael
AU - Harder Clemmensen, Line
AU - Didriksen, Maria
AU - Nyegaard, Mette
AU - Hjalgrim, Henrik
AU - René Nielsen, Kaspar
AU - Topholm Bruun, Mie
AU - Rye Ostrowski, Sisse
AU - Erikstrup, Christian
AU - Mikkelsen, Susan
AU - Sørensen, Erik
AU - DBDS Genomic Consortium
AU - Birger Vestager Pedersen, Ole
AU - Brunak, Søren
AU - Banasik, Karina
AU - Nicola Giordano, Giuseppe
N1 - © 2024. The Author(s).
PY - 2024/1/16
Y1 - 2024/1/16
N2 - Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brainrelated phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent metaanalysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.
AB - Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brainrelated phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent metaanalysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.
UR - http://www.scopus.com/inward/record.url?scp=85182480285&partnerID=8YFLogxK
U2 - 10.1038/s41598-024-51636-0
DO - 10.1038/s41598-024-51636-0
M3 - Journal article
C2 - 38228779
SN - 2045-2322
VL - 14
SP - 1
EP - 12
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 1402
ER -