Abstract
Long-term potentiation (LTP) has been extensively studied with rodents and human subjects to understand pain mechanisms. This phenomenon remains relatively less explored in pigs, even though pigs present a suitable translational model for neurophysiological research. This study aimed to investigate changes in the spike activity in the primary somatosensory cortex (S1) in response to spinal LTP-like neuroplasticity induced by high-frequency electrical stimulation (HFS) in Danish landrace pigs. Six animals were investigated (two controls and four interventions). A 16-channel multi-electrode array was implanted into the S1. A tripolar cuff was placed around the ulnar nerve. HFS (15 mA, 100 Hz, 1 ms) was induced on the ulnar nerve branches to induce LTP-like neuroplasticity, followed by non-nociceptive stimulation to probe the S1 response. Peristimulus time histograms (PSTHs) were constructed based on the neuronal spikes detected from S1. For the intervention group, the PSTH showed a significant increase in the area under the curve (AVC) 45 min (T2 phase) after applying the HFS. These results were in line with findings based on local-field potentials, i.e., the cortical excitability increased immediately after intervention and became significantly greater during the T2 phase. The result of this study is believed to be an essential contribution to developing a translational, large-animal model of LTP-like pain to bridge research between animal models and clinical applications.
Original language | English |
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Title of host publication | 11th International IEEE/EMBS Conference on Neural Engineering, NER 2023 - Proceedings |
Publisher | IEEE |
Publication date | 24 Apr 2023 |
Article number | 10123841 |
ISBN (Print) | 978-1-6654-6293-8 |
ISBN (Electronic) | 978-1-6654-6292-1 |
DOIs | |
Publication status | Published - 24 Apr 2023 |
Event | 11th International IEEE/EMBS Conference on Neural Engineering (2023 NER) - Baltimore, United States Duration: 24 Apr 2023 → 27 Apr 2023 https://cid.wse.jhu.edu/blog/ieee-embs-2023/ |
Conference
Conference | 11th International IEEE/EMBS Conference on Neural Engineering (2023 NER) |
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Country/Territory | United States |
City | Baltimore |
Period | 24/04/2023 → 27/04/2023 |
Internet address |
Series | International IEEE/EMBS Conference on Neural Engineering, NER |
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ISSN | 1948-3546 |
Bibliographical note
Funding Agency:10.13039/501100001732-Danish National Research Foundation (Grant Number: DNRF121)
Keywords
- LTP-like neuroplasticity
- Long-term potentiation
- animal model
- primary somatosensory cortex