Kombinationsbehandling med thyroxin og trijodthyronin til patienter med hypotyreose

Birte Nygaard, Michael E Røder, Jesper Karmisholt, Jette Kolding Kristensen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstract

Decreased quality of life is described more often in hypothyroid patients, who are treated with a synthetic form of thyroxine (L-T4), than in euthyroid controls. A combination of L-T4 and a synthetic form of triiodothyronine (L-T3) has been suggested; however, previous meta-analyses on unselected patients did not find any effect. Recent studies demonstrate, that the overall hypothalamic-pituitary-thyroid-tissue homeostasis could be more complex than previously suggested. Polymorphisms in deiodinase and thyroid hormone transporter genes could theoretically explain, why a minor subgroup of hypothyroid patients seem to have an effect of L-T4/L-T3 combination therapy.

Bidragets oversatte titelCombination therapy of thyroxine and triiodothyronine in hypothyroid patients
OriginalsprogDansk
ArtikelnummerV04170328
TidsskriftUgeskrift for Laeger
Vol/bind180
Udgave nummer19
Sider (fra-til)2-5
Antal sider4
ISSN0041-5782
StatusUdgivet - 2018

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