The neurophysiology of the esophagus

Philip Woodland, Daniel Sifrim, Anne Lund Krarup, Christina Brock, Jens Brøndum Frøkjaer, Christian Lottrup, Asbjørn Mohr Drewes, Lee L Swanstrom, Adam D Farmer

Publikation: Bidrag til tidsskriftKonferenceartikel i tidsskriftForskningpeer review

11 Citationer (Scopus)

Abstrakt

This paper reports on the neurophysiology of the esophagus, including on the uneven distribution of innervation in the esophagus, reflected by the increased sensitivity and perception of gastroesophageal reflux disease (GERD) events in the proximal rather than distal esophagus; the role of the enteric nervous system (ENS) in swallowing; the role of the physiological stress-responsive systems, including the autonomic nervous system (ANS) and the hypothalamic-pituitary-adrenal (HPA) axis in mediating esophageal pain; the advances in understanding pain mechanisms and brain structure provided by technological imaging advances; investigations into the efficacy of the descending-pain control system, including diffuse noxious inhibitory control (DNIC); the role of abnormal nervous signaling in afferent pathways in the pathogenesis of Barrett's esophagus (BE); and the contribution of the esophageal mucosa to reflux symptoms.
OriginalsprogEngelsk
TidsskriftAnnals of the New York Academy of Sciences
Vol/bind1300
Udgave nummer1
Sider (fra-til)53-70
Antal sider18
ISSN0077-8923
DOI
StatusUdgivet - okt. 2013
BegivenhedWorld Congress of the World Organization for Specialized Studies on Diseases of the Esophagus - Como, Italien
Varighed: 1 sep. 20124 sep. 2012
Konferencens nummer: 11

Konference

KonferenceWorld Congress of the World Organization for Specialized Studies on Diseases of the Esophagus
Nummer11
Land/OmrådeItalien
ByComo
Periode01/09/201204/09/2012

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