Is post-covid pain associated with single nucleotide polymorphisms in covid-19 survivors who had been hospitalized? A summarizing study

Rocco Giordano; C. Fernández-de-las-Penas; Gema Díaz-Gil; Antonio Gil-Crujera; Stella M. Gómez-Sánchez; Silvia Ambite-Quesada; Lars Arendt-Nielsen

Abstract

Background and aims: The role of single nucleotide polymorphisms (SNP) in the acute phase of coronavirus disease, 2019 (COVID-19) has been investigated. Different SNP have been associated with a more severe condition. The current study aimed to investigate the association between different selected SNP with the presence of de novo post-COVID pain symptoms in a sample of previously hospitalized COVID-19 survivors.

Methods: No-stimulated saliva samples were collected from 293 (49.5% female, age: 55.6±12.9 years) previously hospitalized COVID-19 survivors. Three different types of SNP were investigated: 1, pain-related: OPRM1_rs1799971, COMT_rs4680, BDNF_ rs6265, HTR1B_rs6296; 2, inflammatory-related: IL-6_rs1800796, IL-10_rs1800896, TNF-α_rs1800629, IFITM3_rs12252; and, 3, COVID-19 related: ACE2_rs2285666, ACE2_rs2074192, ACE1_rs1799752; TMPRSS2_rs12329760, TMPRSS2 _ rs2070788.
Three potential genotypes of each SNPs were identified. The presence of post-COVID pain symptoms, intensity and duration of pain were assessed in a face-to-face interview conducted at 17.8 ± 5.2 months after hospitalization.

Results: One hundred and seventeen (39.9%) experienced post-COVID pain, particularly defined of musculoskeletal origin. Overall, the distribution of the genotype variants of any SNP were not significantly different between COVID-19 survivors with and without de novo post-COVID pain symptoms (all, P>0.151). No effect of gender was identified for any SNP.

Conclusions: The current summarizing study found that different SNPs associated with pain, inflammatory and immune responses, and COVID-19 acute severity did not appear to predispose for the development of de novo long-COVID pain symptoms in previously hospitalized COVID-19 survivors.

Original language	English
Publication date	Sept 2023
Publication status	Published - Sept 2023
Event	13th Congress of the European Pain Federation EFIC: Personalised Pain Management: The Future is Now - Budapest, Hungary Duration: 20 Sept 2023 → 22 Sept 2023 https://europeanpainfederation.eu/efic2023/

Conference

Conference	13th Congress of the European Pain Federation EFIC
Country/Territory	Hungary
City	Budapest
Period	20/09/2023 → 22/09/2023
Internet address	https://europeanpainfederation.eu/efic2023/

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@conference{f414e9827e8a42cdafadee9ade626d3f,

title = "Is post-covid pain associated with single nucleotide polymorphisms in covid-19 survivors who had been hospitalized? A summarizing study",

abstract = "Background and aims: The role of single nucleotide polymorphisms (SNP) in the acute phase of coronavirus disease, 2019 (COVID-19) has been investigated. Different SNP have been associated with a more severe condition. The current study aimed to investigate the association between different selected SNP with the presence of de novo post-COVID pain symptoms in a sample of previously hospitalized COVID-19 survivors.Methods: No-stimulated saliva samples were collected from 293 (49.5% female, age: 55.6±12.9 years) previously hospitalized COVID-19 survivors. Three different types of SNP were investigated: 1, pain-related: OPRM1_rs1799971, COMT_rs4680, BDNF_ rs6265, HTR1B_rs6296; 2, inflammatory-related: IL-6_rs1800796, IL-10_rs1800896, TNF-α_rs1800629, IFITM3_rs12252; and, 3, COVID-19 related: ACE2_rs2285666, ACE2_rs2074192, ACE1_rs1799752; TMPRSS2_rs12329760, TMPRSS2 _ rs2070788.Three potential genotypes of each SNPs were identified. The presence of post-COVID pain symptoms, intensity and duration of pain were assessed in a face-to-face interview conducted at 17.8 ± 5.2 months after hospitalization.Results: One hundred and seventeen (39.9%) experienced post-COVID pain, particularly defined of musculoskeletal origin. Overall, the distribution of the genotype variants of any SNP were not significantly different between COVID-19 survivors with and without de novo post-COVID pain symptoms (all, P>0.151). No effect of gender was identified for any SNP.Conclusions: The current summarizing study found that different SNPs associated with pain, inflammatory and immune responses, and COVID-19 acute severity did not appear to predispose for the development of de novo long-COVID pain symptoms in previously hospitalized COVID-19 survivors.",

author = "Rocco Giordano and C. Fern{\'a}ndez-de-las-Penas and Gema D{\'i}az-Gil and Antonio Gil-Crujera and G{\'o}mez-S{\'a}nchez, {Stella M.} and Silvia Ambite-Quesada and Lars Arendt-Nielsen",

year = "2023",

month = sep,

language = "English",

note = "13th Congress of the European Pain Federation EFIC ; Conference date: 20-09-2023 Through 22-09-2023",

url = "https://europeanpainfederation.eu/efic2023/",

}

Giordano, R, Fernández-de-las-Penas, C, Díaz-Gil, G, Gil-Crujera, A, Gómez-Sánchez, SM, Ambite-Quesada, S & Arendt-Nielsen, L 2023, 'Is post-covid pain associated with single nucleotide polymorphisms in covid-19 survivors who had been hospitalized? A summarizing study', 13th Congress of the European Pain Federation EFIC, Budapest, Hungary, 20/09/2023 - 22/09/2023.

Is post-covid pain associated with single nucleotide polymorphisms in covid-19 survivors who had been hospitalized? A summarizing study. / Giordano, Rocco; Fernández-de-las-Penas, C.; Díaz-Gil, Gema et al.
2023. Abstract from 13th Congress of the European Pain Federation EFIC, Budapest, Hungary.

Research output: Contribution to conference without publisher/journal › Conference abstract for conference › Research › peer-review

TY - ABST

T1 - Is post-covid pain associated with single nucleotide polymorphisms in covid-19 survivors who had been hospitalized? A summarizing study

AU - Giordano, Rocco

AU - Fernández-de-las-Penas, C.

AU - Díaz-Gil, Gema

AU - Gil-Crujera, Antonio

AU - Gómez-Sánchez, Stella M.

AU - Ambite-Quesada, Silvia

AU - Arendt-Nielsen, Lars

PY - 2023/9

Y1 - 2023/9

N2 - Background and aims: The role of single nucleotide polymorphisms (SNP) in the acute phase of coronavirus disease, 2019 (COVID-19) has been investigated. Different SNP have been associated with a more severe condition. The current study aimed to investigate the association between different selected SNP with the presence of de novo post-COVID pain symptoms in a sample of previously hospitalized COVID-19 survivors.Methods: No-stimulated saliva samples were collected from 293 (49.5% female, age: 55.6±12.9 years) previously hospitalized COVID-19 survivors. Three different types of SNP were investigated: 1, pain-related: OPRM1_rs1799971, COMT_rs4680, BDNF_ rs6265, HTR1B_rs6296; 2, inflammatory-related: IL-6_rs1800796, IL-10_rs1800896, TNF-α_rs1800629, IFITM3_rs12252; and, 3, COVID-19 related: ACE2_rs2285666, ACE2_rs2074192, ACE1_rs1799752; TMPRSS2_rs12329760, TMPRSS2 _ rs2070788.Three potential genotypes of each SNPs were identified. The presence of post-COVID pain symptoms, intensity and duration of pain were assessed in a face-to-face interview conducted at 17.8 ± 5.2 months after hospitalization.Results: One hundred and seventeen (39.9%) experienced post-COVID pain, particularly defined of musculoskeletal origin. Overall, the distribution of the genotype variants of any SNP were not significantly different between COVID-19 survivors with and without de novo post-COVID pain symptoms (all, P>0.151). No effect of gender was identified for any SNP.Conclusions: The current summarizing study found that different SNPs associated with pain, inflammatory and immune responses, and COVID-19 acute severity did not appear to predispose for the development of de novo long-COVID pain symptoms in previously hospitalized COVID-19 survivors.

AB - Background and aims: The role of single nucleotide polymorphisms (SNP) in the acute phase of coronavirus disease, 2019 (COVID-19) has been investigated. Different SNP have been associated with a more severe condition. The current study aimed to investigate the association between different selected SNP with the presence of de novo post-COVID pain symptoms in a sample of previously hospitalized COVID-19 survivors.Methods: No-stimulated saliva samples were collected from 293 (49.5% female, age: 55.6±12.9 years) previously hospitalized COVID-19 survivors. Three different types of SNP were investigated: 1, pain-related: OPRM1_rs1799971, COMT_rs4680, BDNF_ rs6265, HTR1B_rs6296; 2, inflammatory-related: IL-6_rs1800796, IL-10_rs1800896, TNF-α_rs1800629, IFITM3_rs12252; and, 3, COVID-19 related: ACE2_rs2285666, ACE2_rs2074192, ACE1_rs1799752; TMPRSS2_rs12329760, TMPRSS2 _ rs2070788.Three potential genotypes of each SNPs were identified. The presence of post-COVID pain symptoms, intensity and duration of pain were assessed in a face-to-face interview conducted at 17.8 ± 5.2 months after hospitalization.Results: One hundred and seventeen (39.9%) experienced post-COVID pain, particularly defined of musculoskeletal origin. Overall, the distribution of the genotype variants of any SNP were not significantly different between COVID-19 survivors with and without de novo post-COVID pain symptoms (all, P>0.151). No effect of gender was identified for any SNP.Conclusions: The current summarizing study found that different SNPs associated with pain, inflammatory and immune responses, and COVID-19 acute severity did not appear to predispose for the development of de novo long-COVID pain symptoms in previously hospitalized COVID-19 survivors.

UR - https://efic2023.abstractserver.com/program/#/details/presentations/259

M3 - Conference abstract for conference

T2 - 13th Congress of the European Pain Federation EFIC

Y2 - 20 September 2023 through 22 September 2023

ER -

Is post-covid pain associated with single nucleotide polymorphisms in covid-19 survivors who had been hospitalized? A summarizing study

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