Abstract
Background and aims: The role of single nucleotide polymorphisms (SNP) in the acute phase of coronavirus disease, 2019 (COVID-19) has been investigated. Different SNP have been associated with a more severe condition. The current study aimed to investigate the association between different selected SNP with the presence of de novo post-COVID pain symptoms in a sample of previously hospitalized COVID-19 survivors.
Methods: No-stimulated saliva samples were collected from 293 (49.5% female, age: 55.6±12.9 years) previously hospitalized COVID-19 survivors. Three different types of SNP were investigated: 1, pain-related: OPRM1_rs1799971, COMT_rs4680, BDNF_ rs6265, HTR1B_rs6296; 2, inflammatory-related: IL-6_rs1800796, IL-10_rs1800896, TNF-α_rs1800629, IFITM3_rs12252; and, 3, COVID-19 related: ACE2_rs2285666, ACE2_rs2074192, ACE1_rs1799752; TMPRSS2_rs12329760, TMPRSS2 _ rs2070788.
Three potential genotypes of each SNPs were identified. The presence of post-COVID pain symptoms, intensity and duration of pain were assessed in a face-to-face interview conducted at 17.8 ± 5.2 months after hospitalization.
Three potential genotypes of each SNPs were identified. The presence of post-COVID pain symptoms, intensity and duration of pain were assessed in a face-to-face interview conducted at 17.8 ± 5.2 months after hospitalization.
Results: One hundred and seventeen (39.9%) experienced post-COVID pain, particularly defined of musculoskeletal origin. Overall, the distribution of the genotype variants of any SNP were not significantly different between COVID-19 survivors with and without de novo post-COVID pain symptoms (all, P>0.151). No effect of gender was identified for any SNP.
Conclusions: The current summarizing study found that different SNPs associated with pain, inflammatory and immune responses, and COVID-19 acute severity did not appear to predispose for the development of de novo long-COVID pain symptoms in previously hospitalized COVID-19 survivors.
Originalsprog | Engelsk |
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Publikationsdato | sep. 2023 |
Status | Udgivet - sep. 2023 |
Begivenhed | 13th Congress of the European Pain Federation EFIC: Personalised Pain Management: The Future is Now - Budapest, Ungarn Varighed: 20 sep. 2023 → 22 sep. 2023 https://europeanpainfederation.eu/efic2023/ |
Konference
Konference | 13th Congress of the European Pain Federation EFIC |
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Land/Område | Ungarn |
By | Budapest |
Periode | 20/09/2023 → 22/09/2023 |
Internetadresse |