Klinisk anvendelse af polygene risikoscorer

Thorkild Terkelsen; Thomas Folkmann Hansen; Morten Krogh Herlin; Malene Djursby; Mette Nyegaard; Inge Søkilde Pedersen; Dorte Launholt Lildballe; Søren Lejsted Færgeman; Lone Sunde; Mads Engel Hauberg

Klinisk anvendelse af polygene risikoscorer

Thorkild Terkelsen, Thomas Folkmann Hansen, Morten Krogh Herlin, Malene Djursby, Mette Nyegaard, Inge Søkilde Pedersen, Dorte Launholt Lildballe, Søren Lejsted Færgeman, Lone Sunde, Mads Engel Hauberg^*

^*Kontaktforfatter

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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Abstract

Polygenic risk scores (PRS) identify at-risk individuals for many common diseases. A discussion of strengths and limitations is carried out in this review. PRS complement traditional genetic testing and have shown utility in establishing a proper diagnosis and guiding primary and secondary prevention. Some individuals with high PRS have risks similar to those with monogenic predisposition. Limitations include potential misinterpretations, problems with application across ancestries, and limited usefulness in low-heritability traits. Despite its shortcomings PRS are predicted to play major roles in the future of personal medicine and genetic testing.

Bidragets oversatte titel	The clinical use of polygenic risk scores
Originalsprog	Dansk
Artikelnummer	V04230258
Tidsskrift	Ugeskrift for Læger
Vol/bind	185
ISSN	0041-5782
Status	Udgivet - 25 sep. 2023

Bibliografisk note

Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.

Emneord

Humans
Risk Factors
Genetic Testing
Medicine
Secondary Prevention
Genetic Predisposition to Disease
Genome-Wide Association Study

Adgang til dokumentet

Terkelsen et al. (2023). Klinisk anvendelse af polygene risikoscorerForlagets udgivne version, 0,99 MBLicens: CC BY-NC-ND 4.0

https://ugeskriftet.dk/videnskab/klinisk-anvendelse-af-polygene-risikoscorerLicens: CC BY-NC-ND 4.0

AUB Link

Søg efter materialet i Aalborg Universitetsbiblioteks søgemaskine

Citationsformater

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abstract = "Polygenic risk scores (PRS) identify at-risk individuals for many common diseases. A discussion of strengths and limitations is carried out in this review. PRS complement traditional genetic testing and have shown utility in establishing a proper diagnosis and guiding primary and secondary prevention. Some individuals with high PRS have risks similar to those with monogenic predisposition. Limitations include potential misinterpretations, problems with application across ancestries, and limited usefulness in low-heritability traits. Despite its shortcomings PRS are predicted to play major roles in the future of personal medicine and genetic testing.",

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T1 - Klinisk anvendelse af polygene risikoscorer

AU - Terkelsen, Thorkild

AU - Hansen, Thomas Folkmann

AU - Herlin, Morten Krogh

AU - Djursby, Malene

AU - Nyegaard, Mette

AU - Pedersen, Inge Søkilde

AU - Lildballe, Dorte Launholt

AU - Færgeman, Søren Lejsted

AU - Sunde, Lone

AU - Hauberg, Mads Engel

N1 - Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.

PY - 2023/9/25

Y1 - 2023/9/25

N2 - Polygenic risk scores (PRS) identify at-risk individuals for many common diseases. A discussion of strengths and limitations is carried out in this review. PRS complement traditional genetic testing and have shown utility in establishing a proper diagnosis and guiding primary and secondary prevention. Some individuals with high PRS have risks similar to those with monogenic predisposition. Limitations include potential misinterpretations, problems with application across ancestries, and limited usefulness in low-heritability traits. Despite its shortcomings PRS are predicted to play major roles in the future of personal medicine and genetic testing.

AB - Polygenic risk scores (PRS) identify at-risk individuals for many common diseases. A discussion of strengths and limitations is carried out in this review. PRS complement traditional genetic testing and have shown utility in establishing a proper diagnosis and guiding primary and secondary prevention. Some individuals with high PRS have risks similar to those with monogenic predisposition. Limitations include potential misinterpretations, problems with application across ancestries, and limited usefulness in low-heritability traits. Despite its shortcomings PRS are predicted to play major roles in the future of personal medicine and genetic testing.

KW - Humans

KW - Risk Factors

KW - Genetic Testing

KW - Medicine

KW - Secondary Prevention

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

M3 - Tidsskriftartikel

C2 - 37873989

SN - 0041-5782

VL - 185

JO - Ugeskrift for Læger

JF - Ugeskrift for Læger

M1 - V04230258

ER -

Klinisk anvendelse af polygene risikoscorer

Abstract

Bibliografisk note

Emneord

Adgang til dokumentet

AUB Link

Fingeraftryk

Citationsformater