Photo of Annette Burkhart Larsen

Annette Burkhart Larsen

Kandidat i Medicin med Industriel Specialisering - Biomedicin

  • Fredrik Bajers Vej 7, D, D2-111

    9220 Aalborg Ø

    Denmark

20112019
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Research Output 2011 2019

2019
Hepcidins
Ficus
PC12 Cells
Iron
Messenger RNA
1 Citation (Scopus)
Hepcidins
PC12 Cells
Iron
Messenger RNA
Deferoxamine
5 Citations (Scopus)

Modulating the antibody density changes the uptake and transport at the blood-brain barrier of both transferrin receptor-targeted gold nanoparticles and liposomal cargo

Johnsen, K. B., Bak, M., Melander, F., Thomsen, M. S., Burkhart, A., Kempen, P. J., Andresen, T. L. & Moos, T., 10 Feb 2019, In : Journal of Controlled Release. 295, p. 237-249 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Transferrin Receptors
Blood-Brain Barrier
Gold
Nanoparticles
Antibodies
2018
8 Citations (Scopus)
523 Downloads (Pure)

Antibody affinity and valency impact brain uptake of transferrin receptor-targeted gold nanoparticles

Johnsen, K. B., Bak, M., Kempen, P. J., Melander, F., Burkhart, A., Thomsen, M. S., Nielsen, M. S., Moos, T. & Andresen, T. L., 2018, In : Theranostics. 8, 12, p. 3416-3436

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Transferrin Receptors
Antibody Affinity
Gold
Nanoparticles
Nanomedicine
2017
13 Citations (Scopus)
Endothelial cells
Pericytes
Blood-Brain Barrier
Basement Membrane
Brain
32 Citations (Scopus)
31 Downloads (Pure)

Targeting transferrin receptors at the blood-brain barrier improves the uptake of immunoliposomes and subsequent cargo transport into the brain parenchyma

Johnsen, K. B., Burkhart, A., Melander, F., Kempen, P. J., Vejlebo, J. B., Siupka, P., Nielsen, M. S., Andresen, T. L. & Moos, T., 1 Dec 2017, In : Scientific Reports. 7, 13 p., 10396.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Transferrin Receptors
Blood-Brain Barrier
Brain
Endothelium
Transcytosis
1 Citation (Scopus)
Erythropoietin
Transfection
Endothelial Cells
Brain
Proteins
2016

A triple co-culture model of the blood-brain barrier using primary porcine brain endothelial cells, porcine pericytes and porcine astrocytes

Thomsen, L. B., Larsen, A. B. & Moos, T., 2016, IPC No. C12N 5/071 (2010.01), C12N 5/079 (2010.01), G01N 33/50 (2006.01), Patent No. WO/2016/202343 , 22 Dec 2016, Priority date 16 Jun 2016, Priority No. PCT/DK2016/050190

Research output: PatentResearch

Open Access

Expression and deposition of basement membrane proteins by brain capillary endothelial cells in a primary murine model of the blood-brain barrier

Thomsen, M. S., Birkelund, S., Larsen, A. B., Stensballe, A. & Moos, T., 2016, Final Programme, 19th International Symposium on Signal Transduction at the Blood-Brain Barriers, 14-16 September 2016, Copenhagen, Denmark. University of Copenhagen, p. 37 P-12

Research output: Contribution to book/anthology/report/conference proceedingConference abstract in proceedingResearchpeer-review

22 Citations (Scopus)

Expression of iron-related proteins at the neurovascular unit supports reduction and reoxidation of iron for transport through the blood-brain barrier

Burkhart, A., Skjørringe, T., Johnsen, K. B., Siupka, P., Thomsen, L. B., Nielsen, M. S., Thomsen, L. L. & Moos, T., 2016, In : Molecular Neurobiology. 53, 10, p. 7237-7253

Research output: Contribution to journalJournal articleResearchpeer-review

Blood-Brain Barrier
Iron
Ceruloplasmin
Brain
Endothelial Cells

Gene delivery of the therapeutic polypeptide erythropoietin to primary brain capillary endothelial cells for protein secretion

Larsen, A. B. & Moos, T., 2016, Final Programme, 19th International Symposium on Signal Transduction at the Blood-Brain Barriers, 14-16 September 2016, Copenhagen, Denmark. University of Copenhagen, p. 25 O-5

Research output: Contribution to book/anthology/report/conference proceedingConference abstract in proceedingResearchpeer-review

Synthesis and deposition of basement membrane proteins by primary brain capillary endothelial cells in a murine model of the blood-brain barrier

Moos, T., Routhe, L. J., Birkelund, S., Burkhart, A., Stensballe, A. & Thomsen, M. S., 2016, 46th Annual Meeting of the Society for Neuroscience, Neuroscience 2016, 12-16 November 2016, San Diego, CA, USA. Society for Neuroscience, 140.10 / U1

Research output: Contribution to book/anthology/report/conference proceedingConference abstract in proceedingResearchpeer-review

Open Access

Targeting immunoliposomes to transferrin receptors on brain capillary endothelial cells as a mean for cargo transport across the blood-brain barrier

Moos, T., Johnsen, K. B., Burkhart, A., Bruun, J., Siupka, P., Nielsen, M. S. & Andresen, T., 2016, 46th Annual Meeting of the Society for Neuroscience, Neuroscience 2016, 12-16 November 2016, San Diego, CA, USA. Society for Neuroscience, 140.13 / U4

Research output: Contribution to book/anthology/report/conference proceedingConference abstract in proceedingResearchpeer-review

Open Access

Targeting immunoliposomes to transferrin receptors on brain capillary endothelial cells as a mean for cargo transport across the blood-brain barrier

Johnsen, K. B., Larsen, A. B., Bruun, J., Siupka, P., Nielsen, M. S., Andresen, T. L. & Moos, T., 2016, Final Programme, 19th International Symposium on Signal Transduction at the Blood-Brain Barriers, 14-16 September 2016, Copenhagen, Denmark. University of Copenhagen, p. 51 P-51

Research output: Contribution to book/anthology/report/conference proceedingConference abstract in proceedingResearchpeer-review

2015
48 Citations (Scopus)
196 Downloads (Pure)

A triple culture model of the blood-brain barrier using porcine brain endothelial cells, astrocytes and pericytes

Thomsen, L. B., Burkhart, A. & Moos, T., 2015, In : PLOS ONE. 10, 8, 16 p., e0134765.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Pericytes
blood-brain barrier
astrocytes
Endothelial cells
Blood-Brain Barrier
46 Citations (Scopus)
183 Downloads (Pure)
Open Access
File
19 Citations (Scopus)
227 Downloads (Pure)

Transfection of brain capillary endothelial cells in primary culture with defined blood-brain barrier properties

Larsen, A. B., Thomsen, L. B., Thomsen, M. S., Lichota, J., Fazakas, C., Krizbai, I. & Moos, T., 2015, In : Fluids and Barriers of the CNS. 12, 1, 14 p., 19.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Blood-Brain Barrier
Transfection
Endothelial Cells
Brain
Astrocytes
2014
7 Citations (Scopus)

Accessing targeted nanoparticles to the brain: the vascular route

Burkhart, A., Azizi, M., Thomsen, M. S., Thomsen, L. B. & Moos, T., 2014, In : Current Medicinal Chemistry. 21, 36, p. 4092-4099

Research output: Contribution to journalJournal articleResearchpeer-review

Ceruloplasmin is expressed by brain pericytes

Moos, T. & Larsen, A. B., 2014, Annual Meeting of the Society for Neuroscience, Neuroscience 2014, 15-19 November 2014, Washington, DC, USA. p. Poster No. 739.01/QQ4

Research output: Contribution to book/anthology/report/conference proceedingConference abstract in proceedingResearch

Gene delivery of therapeutic polypeptides to brain capillary endothelial cells for protein secretion

Larsen, A. B., Thomsen, L. B. & Moos, T., 2014.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

Iron uptake and transport at the blood-brain barrier

Larsen, A. B., Thomsen, L. B. & Moos, T., 2014.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

Blood-Brain Barrier
Iron
Gene Expression
Brain
Endothelial Cells
2013

Transfection of rat brain endothelium in a primary culture model of the blood-brain barrier at different states of barrier maturity

Larsen, A. B., Thomsen, L. B., Lichota, J. & Moos, T., 2013.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

2012

Gene delivery into primary brain capillary endothelial cells for protein secretion: a novel strategy for drug delivery to the brain

Larsen, A. B., Thomsen, L. B., Lichota, J. & Moos, T., 2012.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

Endothelial Cells
Brain
Blood-Brain Barrier
Pharmaceutical Preparations
Genes
2011

Gene delivery of therapeutic polypeptides into brain capillary endothelial cells for protein secretion

Moos, T., Larsen, A. B., Thomsen, L. B. & Lichota, J., 2011.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

Gene delivery of therapeutic polypeptides into brain capillary endothelial cells for protein secretion

Larsen, A. B., Thomsen, L. B., Moos, T. & Lichota, J., 2011.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review